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Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres
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KLHL5 Contributes to Colorectal Cancer Cell Survival by Promoting Cell Cycle Progression and Suppressing Apoptotic

Kyosuke Habu1,2, Yosuke Matsuoka3, Hiromi Hiyoshi4

  • 1Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, Toon, Japan.

Cancer Science
|July 1, 2025
PubMed
Summary

Kelch-like protein 5 (KLHL5) promotes colorectal cancer (CRC) cell survival by enhancing cell cycle progression and preventing apoptosis. KLHL5 depletion halts CRC cell growth and triggers programmed cell death, indicating its role as a survival factor.

Keywords:
KLHL5anti‐cell deathbiomarkercell cyclecolorectal cancer

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