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Related Concept Videos

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Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
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Physical assessment of the respiratory tract through inspection is a crucial step in understanding the patient's respiratory health. It provides insights into the functioning of the respiratory system, the musculoskeletal structure, and even the patient's nutritional status. This comprehensive approach involves observing several vital aspects: chest configuration, breathing patterns, respiratory rates, skin color, and use of accessory muscles.
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Related Experiment Video

Updated: Sep 17, 2025

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
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Serum Ang 1, Ang 1-7, and Mas levels as potential biomarkers in obstructive sleep apnea syndrome.

Gizem Çil1, Ömer Araz2, Buğra Kerget2

  • 1Department of Pulmonary Diseases, Siirt Education and Research Hospital, Siirt, Türkiye.

Biomarkers in Medicine
|July 1, 2025
PubMed
Summary

Reduced levels of angiotensin 1-7 (Ang 1-7), angiotensin 1 (Ang 1), and Mas receptor are linked to obstructive sleep apnea (OSA) severity. These biomarkers show promise for identifying moderate-to-severe OSA cases.

Keywords:
Ang 1-4MasRAASobstructive sleep apnea syndromepolysomnography

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Area of Science:

  • Cardiovascular Research
  • Sleep Medicine
  • Biomarker Discovery

Background:

  • Obstructive sleep apnea (OSA) disrupts the inflammatory and anti-inflammatory balance.
  • The renin-angiotensin system plays a role in inflammatory processes relevant to OSA.

Purpose of the Study:

  • To investigate the association between serum levels of angiotensin 1 (Ang 1), angiotensin 1-7 (Ang 1-7), and Mas receptor and the severity of OSA.
  • To evaluate the diagnostic potential of these biomarkers in stratifying OSA patients.

Main Methods:

  • 190 subjects underwent polysomnography to assess OSA severity (Apnea-Hypopnea Index, AHI).
  • Serum concentrations of Ang 1, Ang 1-7, and Mas receptor were quantified using ELISA.
  • Patients were categorized into control, mild, moderate, and severe OSA groups.

Main Results:

  • Serum levels of Ang 1-7, Ang 1, and Mas were significantly lower in moderate and severe OSA groups compared to mild OSA and control groups (p < 0.001).
  • Significant negative correlations were observed between these biomarkers and AHI (e.g., Ang 1-7: R = -0.597, p < 0.001).
  • Receiver Operating Characteristic (ROC) analysis indicated strong diagnostic performance, with Area Under the Curve (AUC) values of 0.864 for Ang 1-7, 0.873 for Ang 1, and 0.837 for Mas, and high sensitivity (97-98%).

Conclusions:

  • Decreased serum levels of Ang 1-7, Ang 1, and Mas are associated with increased OSA severity.
  • These biomarkers exhibit significant diagnostic value and may aid in the clinical stratification of patients with moderate-to-severe OSA.