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  1. Home
  3. Serum Ang 1, Ang 1-7, And Mas Levels As Potential Biomarkers In Obstructive Sleep Apnea Syndrome.
  1. Home
  3. Serum Ang 1, Ang 1-7, And Mas Levels As Potential Biomarkers In Obstructive Sleep Apnea Syndrome.

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Serum Ang 1, Ang 1-7, and Mas levels as potential biomarkers in obstructive sleep apnea syndrome.

Gizem Çil1, Ömer Araz2, Buğra Kerget2

  • 1Department of Pulmonary Diseases, Siirt Education and Research Hospital, Siirt, Türkiye.

Biomarkers in Medicine
|July 1, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Reduced levels of angiotensin 1-7 (Ang 1-7), angiotensin 1 (Ang 1), and Mas receptor are linked to obstructive sleep apnea (OSA) severity. These biomarkers show promise for identifying moderate-to-severe OSA cases.

Keywords:
Ang 1-4MasRAASobstructive sleep apnea syndromepolysomnography

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Area of Science:

  • Cardiovascular Research
  • Sleep Medicine
  • Biomarker Discovery

Background:

  • Obstructive sleep apnea (OSA) disrupts the inflammatory and anti-inflammatory balance.
  • The renin-angiotensin system plays a role in inflammatory processes relevant to OSA.

Purpose of the Study:

  • To investigate the association between serum levels of angiotensin 1 (Ang 1), angiotensin 1-7 (Ang 1-7), and Mas receptor and the severity of OSA.
  • To evaluate the diagnostic potential of these biomarkers in stratifying OSA patients.

Main Methods:

  • 190 subjects underwent polysomnography to assess OSA severity (Apnea-Hypopnea Index, AHI).
  • Serum concentrations of Ang 1, Ang 1-7, and Mas receptor were quantified using ELISA.
  • Patients were categorized into control, mild, moderate, and severe OSA groups.

Main Results:

  • Serum levels of Ang 1-7, Ang 1, and Mas were significantly lower in moderate and severe OSA groups compared to mild OSA and control groups (p < 0.001).
  • Significant negative correlations were observed between these biomarkers and AHI (e.g., Ang 1-7: R = -0.597, p < 0.001).
  • Receiver Operating Characteristic (ROC) analysis indicated strong diagnostic performance, with Area Under the Curve (AUC) values of 0.864 for Ang 1-7, 0.873 for Ang 1, and 0.837 for Mas, and high sensitivity (97-98%).

Conclusions:

  • Decreased serum levels of Ang 1-7, Ang 1, and Mas are associated with increased OSA severity.
  • These biomarkers exhibit significant diagnostic value and may aid in the clinical stratification of patients with moderate-to-severe OSA.