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Pesticide exposure harms bats, impacting their immune and cognitive functions. Proteomics reveals Chlorpyrifos alters proteins critical for immune response, potentially increasing disease transmission risks.

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Area of Science:

  • Ecotoxicology
  • Proteomics
  • Mammalian Biology

Background:

  • Bats are vital for pest control but face pesticide risks in agricultural areas.
  • Pesticides can impair bat immune function, cognition, and locomotion, threatening their survival.

Purpose of the Study:

  • To investigate the systemic effects of Chlorpyrifos (CPF) on big brown bats (Eptesicus fuscus) using proteomics.
  • To understand how environmentally relevant CPF concentrations impact bat health and ecological roles.

Main Methods:

  • Non-targeted proteomics was used on plasma samples from bats exposed to CPF.
  • Bats were fed CPF at an environmentally relevant concentration for 3 or 7 days.
  • Proteomic analysis identified over 100 proteins with altered abundance post-exposure.

Main Results:

  • CPF exposure significantly altered proteins involved in cell communication, metabolism, and DNA maintenance.
  • Key proteins regulating immune response, T cell activation, and inflammation showed significant changes.
  • These alterations suggest reduced immune function and increased susceptibility to infections in bats.

Conclusions:

  • Proteomics is a valuable tool for assessing pesticide toxicity in bats and other vulnerable species.
  • CPF exposure can compromise bat immunity, potentially increasing risks of pathogen shedding and transmission.
  • Findings have implications for One Health, considering bats' role in zoonotic disease reservoirs.