Exploring the role of protein palmitoylation in cancer progression and therapy: a comprehensive bibliometric study (2004-2024)
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.This bibliometric analysis maps the global research on protein palmitoylation in oncology. Key areas include enzymatic regulation, metabolic reprogramming, and targeted cancer therapies, highlighting emerging trends in tumor biology.
Area Of Science
- Biochemistry and Molecular Biology
- Oncology
- Bioinformatics
Background
- Protein palmitoylation, a crucial post-translational modification, plays a significant role in cellular processes.
- Dysregulation of palmitoylation is increasingly implicated in cancer development and progression.
Purpose Of The Study
- To conduct a comprehensive bibliometric analysis of the research landscape concerning protein palmitoylation in oncology.
- To identify key research hotspots, leading institutions, and emerging trends in this field.
Main Methods
- Data retrieval from the Web of Science Core Collection (2004-2024).
- Bibliometric analysis and data visualization using VOSviewer, CiteSpace, and Microsoft Excel.
- Inclusion of review articles and original research papers.
Main Results
- The United States and China lead in publications, with Shanghai Jiao Tong University as a top institution.
- Research hotspots include enzymatic mechanisms, lipid metabolic reprogramming, signaling pathways, and targeted therapies.
- Emerging trends focus on enzyme modulation, tumor microenvironment metabolism, and therapeutic response.
Conclusions
- This study offers a comprehensive overview of protein palmitoylation research in oncology.
- It highlights the dynamic nature of the field and its implications for cancer treatment.
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
Related Concept Videos
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...