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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
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Related Experiment Video

Updated: Sep 17, 2025

Author Spotlight: Enhancing Diagnostic Strategies and Biomarker Development for Comprehensive Lung Function Analysis
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Pulmonary uptake value (PUV): a new quantification method for lung PET/CT imaging.

Pierre-Yves Le Roux1, Romain Le Pennec2, Vincent Bourbonne3

  • 1Univ Brest, CHU Brest, Médecine Nucléaire, GETBO, INSERM, UMR1304, CHU Cavale Blanche, 29609, Brest Cedex, France. pierre-yves.leroux@chu-brest.fr.

EJNMMI Research
|July 1, 2025
PubMed
Summary

A new quantitative method, pulmonary uptake value (PUV), accurately measures lung perfusion PET/CT imaging. This method normalizes tracer uptake to anatomical lung volume and total activity, overcoming limitations of traditional SUV metrics.

Keywords:
Lung PET/CTLung scintigraphyPUVQuantification

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Area of Science:

  • Nuclear Medicine
  • Radiology
  • Medical Imaging

Background:

  • Lung PET/CT imaging lacks reliable tools for quantifying tracer uptake intensity.
  • Accurate quantification is crucial for assessing lung perfusion, especially post-radiotherapy.

Purpose of the Study:

  • To develop and validate a quantitative approach for lung perfusion PET/CT imaging.
  • To introduce a novel metric, pulmonary uptake value (PUV), for improved quantification.

Main Methods:

  • Analyzed [68Ga]Ga-MAA PET/CT scans from 60 patients before and after radiotherapy.
  • Delineated anatomical lung volume (ALV) on CT, co-registered with PET.
  • Calculated Standardized Uptake Value (SUV), SUVp, and Pulmonary Uptake Value (PUV) for normalization.

Main Results:

  • SUV and SUVp showed inconsistent results and wide variability.
  • PUV demonstrated coherent results, outperforming SUV and SUVp in challenging quantification scenarios.
  • PUV normalization to ALV and total activity proved more reliable than patient weight or injected dose.

Conclusions:

  • Patient weight and injected dose are unsuitable for normalizing lung perfusion quantification.
  • The proposed PUV metric, using ALV and total activity, offers a reliable quantitative approach for lung perfusion PET/CT.
  • PUV enhances the reproducibility and accuracy of lung perfusion imaging analysis.