Related Experiment Video
Updated: Sep 17, 2025

High-Temperature and High-Pressure In situ Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy
Published on: October 9, 2020
High-Resolution 1H/17O NMR Correlation under Fast Magic-Angle Spinning: Revisiting Cross-Polarization for Quadrupolar
1National High Magnetic Field Laboratory, 1800 E. Paul Dirac Drive, Tallahassee, Florida 32310, United States.
Abstract:
An efficient experiment for 1H/17O heteronuclear correlation is presented, combining forward-and-back cross-polarization and low-power cosine multiple-quantum magic-angle spinning methods. Double cross-polarization (DCP) is compared with the heteronuclear multiple-quantum correlation (HMQC) method. Both experiments are applicable in instances of enhanced proton polarization such as with dynamic nuclear polarization. Under fast magic-angle spinning, cross-polarization becomes a viable method for polarization transfer and provides an order of magnitude enhancement over HMQC. In particular, it is observed that faster sample spinning opens up regions of rf fields optimal for spin-locking and cross-polarization with much less T2 signal loss. The incorporation of multiple-quantum magic-angle spinning enables high 17O isotropic resolution via proton detection.
More Related Videos
09:25Author Spotlight: Exploring Intrinsically Disordered Protein Dynamics Through NMR Relaxation Experiments
Published on: November 1, 2024
07:24Paramagnetic Relaxation Enhancement for Detecting and Characterizing Self-Associations of Intrinsically Disordered Proteins
Published on: September 23, 2021
Related Concept Videos
2D NMR: Overview of Heteronuclear Correlation Techniques
2D NMR: Overview of Homonuclear Correlation Techniques
COSY90 is the standard two-dimensional (2D) COSY experiment that...
NMR Spectroscopy: Spin–Spin Coupling
2D NMR: Heteronuclear Single-Quantum Correlation Spectroscopy (HSQC)
2D NMR: Homonuclear Correlation Spectroscopy (COSY)
¹H NMR: Long-Range Coupling
In alkenes, spin information is communicated via σ–π overlap, as seen in allylic (four-bond) and homoallylic (five-bond) couplings. These coupling interactions are stronger when the σ bond is parallel to the alkene...