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Type 2 Uveal Effusion Syndrome with Psoriasis Vulgaris: A Case Report
Chen Zhou1, Yunfeng Lu1, Lingying Ge1
1Department of Ophthalmology, Affiliated First Hospital of Soochow University, Suzhou, Jiangsu, China.
Purpose:
To report the case of uveal effusion syndrome (UES) in a 35-year-old woman with psoriasis vulgaris, emphasizing scleral pathology and systemic inflammatory contributions mediated by proteomic alterations.
Methods:
Medical history, clinical findings and treatment were reviewed, along with histopathological and proteomic analysis.
Results:
A 35-year-old woman presented with retinal and choroidal detachments in the left eye and scleral thickening (3 mm vs. normal 1 mm). Concurrently, her psoriasis symptoms worsened. Histology revealed collagen disorganization and extracellular matrix remodeling in the sclera, accompanied by elevated inflammatory factors (e.g. MCP-4, RANTES, Fractalkine). Treatment included partial sclerotomy, leading to resolution of detachments and improved visual acuity.
Conclusion:
Systemic inflammation associated with psoriasis may contribute to UES pathogenesis. Dermatologists should refer psoriasis patients for ophthalmologic examinations, while ophthalmologists should be aware of underlying health conditions when treating UES.
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