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[Thyroid dysfunction and disorders in deamination of nitrogenous compounds in experimental atherosclerosis]

T Saĭdullaev, M Khuzhamberdiev, N G Aleksandrov

    Problemy Endokrinologii
    |May 1, 1985
    PubMed

    Insights

    Hypothyroidism with hypercholesterolemia decreased monoamine deamination and increased cadaverine activity in rabbit tissues. Hyperthyroidism also altered these enzyme activities, particularly in heart muscle.

    Area of Science:

    • Biochemistry
    • Enzymology
    • Metabolic pathways

    Context:

    • Investigates the impact of altered thyroid states on enzymatic activity in rabbit tissues.
    • Focuses on mitochondrial fractions of liver, brain, and heart.
    • Examines the interplay between thyroid function, cholesterol levels, and amine metabolism.

    Purpose:

    • To elucidate changes in monoamine and cadaverine deamination activities under induced hypothyroidism and hyperthyroidism.
    • To assess the effect of combined hypercholesterolemia on these enzymatic processes.
    • To characterize alterations in AMP deamination in the heart under hyperthyroidism.

    Summary:

    • Hypothyroidism combined with hypercholesterolemia led to decreased monoamine deamination and increased cadaverine deaminating activity in rabbit liver, brain, and heart mitochondria.
    • Hyperthyroidism induced a decrease in monoamine deamination and an increase in cadaverine deaminating activity in the heart muscle mitochondria.
    • A significant increase in AMP deamination was also noted in the heart mitochondria during hyperthyroidism.

    Impact:

    • Provides insights into the biochemical adaptations of key organs to metabolic disturbances.
    • Highlights the differential effects of hypo- and hyperthyroidism on amine metabolism.
    • Suggests potential targets for therapeutic interventions in metabolic and endocrine disorders.

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