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Exploring the pathogenesis of extranodal natural killer/T cell lymphoma complicated With EBV via microarray data
Yin-Yin Peng1, Xiao-Qiong Tang1, Xin Wang1
1Department of Hematology Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Leukemia Research
|July 1, 2025
Summary
This study identified 152 common differentially expressed genes (DEGs) between Extranodal Natural Killer/T-cell lymphoma (ENKL) and Epstein-Barr virus (EBV) infections. Fourteen key hub genes were pinpointed, offering insights into the molecular mechanisms linking EBV and ENKL.
Area of Science:
- Oncology
- Virology
- Genomics
Background:
- Extranodal Natural Killer/T-cell lymphoma (ENKL) is a distinct lymphoma subtype.
- Epstein-Barr virus (EBV) is implicated in the pathogenesis of various lymphoid malignancies, including ENKL.
Purpose of the Study:
- To identify common differentially expressed genes (DEGs) between ENKL and EBV.
- To analyze the enrichment, protein-protein interaction (PPI) network, and hub genes of these common DEGs.
Main Methods:
- Utilized GEO2R to analyze gene expression datasets (GSE85599, GSE169644) from the Gene Expression Omnibus (GEO) database.
- Employed STRING database for PPI network analysis and DAVID database for enrichment analysis.
- Identified hub genes using Cytoscape software.
Main Results:
- Identified 152 DEGs common to ENKL and EBV.
- Discovered 14 significant hub genes, including TOP2A, AURKB, and CDC20.
- Enrichment and PPI analyses indicated that DEGs are predominantly associated with nuclear processes.
Conclusions:
- This research identified common DEGs and 14 hub DEGs potentially mediating the relationship between EBV infection and ENKL.
- The findings provide novel insights into the molecular mechanisms underlying EBV-associated ENKL.
