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Updated: Sep 17, 2025
Capturing Actively Produced Microbial Volatile Organic Compounds from Human-Associated Samples with Vacuum-Assisted Sorbent Extraction
Published on: June 1, 2022
Identification of volatile organic compound as a novel modality for cervical cancer detection
Muhammad Ary Zucha1, Dian Kesumapramudya Nurputra2, Ardhanu Kusumanto1
1Department of Obstetrics and Gynecology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Indonesia.
Objective:
In this study, we developed a novel detection strategy based on volatile organic compound (VOC) sensing. Persistent infection by human papillomavirus (HPV) may cause biological changes in the cervical epithelium, leading to VOC production.
Methods:
This study included 200 urine samples from cervical cancer patients and controls that were HPV-negative. Urine samples were collected and measured using a gas sensor array composed of a matrix of 10 sensors. For each analyzed sample, the instrument produced a vector signal encoding the VOC emitted from the urine (urine prints). The urine prints of cervical cancer patients were differentiated from those of healthy controls.
Results:
Identification of VOC for cervical cancer detection showed reliable accuracy (91% sensitivity, 85% specificity, and 89% accuracy).
Conclusion:
Our.
Results:
demonstrated the applicability of VOC sensing for cervical cancer detection and its potential application in treatment monitoring.
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