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Updated: Sep 17, 2025

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
Published on: May 26, 2022
Finerenone and cardiovascular outcomes in heart failure with mildly reduced and preserved ejection fraction: A
Tess Calcagno1, Rochell Issa2, Faysal Massad1
1Department of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.
Background:
Heart failure with preserved and mildly reduced ejection fraction (HFpEF/HFmrEF) lacks effective therapies. Finerenone, a non-steroidal mineralocorticoid receptor antagonist, may offer cardiovascular benefits in this population.
Methods:
We conducted a retrospective, propensity-matched cohort study using the TriNetX network to compare outcomes in HFpEF/HFmrEF patients treated with finerenone versus no MRA. Primary outcomes included all-cause mortality, acute heart failure hospitalization, and major adverse cardiovascular events (MACE).
Results:
Among 304 matched patients (n = 152 per group), finerenone was associated with significantly lower 1-year mortality (6.6 % vs. 19.7 %, HR 0.24, p = 0.001) and heart failure hospitalization (10.5 % vs. 21.7 %, HR 0.47, p = 0.01). MACE was also reduced at 1 year (35.5 % vs. 47.4 %, HR 0.67, p = 0.022).
Conclusion:
Finerenone use was linked to improved short-term cardiovascular outcomes in patients with HFpEF and HFmrEF, supporting its potential role in this highrisk population.
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