Related Experiment Video
Updated: Sep 17, 2025

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
Published on: May 22, 2014
Aquaporin 9 promotes LPS-induced Eustachian tube inflammation through PP2A/NF-κB pathway
Rui Li1, Xuan Fang2, Huaicun Liu2
1Department of Otolaryngology-Head and Neck Surgery, Peking University First Hospital, Beijing 100034, China.
Abstract:
Eustachian tube dysfunction (ETD) induced by Eustachian tube (ET) inflammation is an important cause to middle ear effusion and hearing impairment. Here, we found that aquaporin 9 (AQP9) was an important regulator of ET inflammation. AQP9 was upregulated during ET inflammation, while AQP9 deficiency alleviated LPS-induced ET inflammation by upregulating protein phosphatase 2A (PP2A) expression to suppress nuclear factor kappa-B (NF-κB) activation through P65 phosphorylation. In addition, pharmacological inhibition of AQP9 by phloretin similarly alleviated ET inflammation. These findings provide a new target for the treatment of ET inflammation to improve ETD.
More Related Videos
09:29Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
Published on: August 21, 2017
12:50Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
Published on: September 15, 2017
Related Concept Videos
Aquaporins
IP3/DAG Signaling Pathway
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The...
Gene Regulation in Microbial Communities: Quorum Sensing
Formation of Lipopolysaccharides
Nitric Oxide Signaling Pathway