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Updated: Sep 17, 2025

Author Spotlight: Standardizing the Development of Amine-Based Silica Composites as CO2 Adsorbents for Direct Air Capture
Published on: September 29, 2023
Advances in biomimetic carbonic anhydrase strategies for CO2 capture
Merve Fedai1, Jialong Shen2, Zsófia Bognár3
1Department of Materials Science and Engineering, North Carolina State University, Raleigh, NC 27695, USA.
Abstract:
Carbonic anhydrase (CA) enzymes hold strong potential in new biotechnological strategies for accelerated CO2 capture and conversion. Some CAs naturally tolerate the harsh conditions associated with carbon capture technologies; however, long-term durability, while maintaining high activity, presents significant challenges. This review offers an in-depth analysis of the CA enzymes that have been investigated for industrial carbon capture processes and highlights the key amino acids and structural features that are crucial for CA activity and stability under harsh conditions. It examines the impact of site-directed protein engineering to enhance CA efficacy and immobilization strategies. Furthermore, it addresses the challenges of scaling up CA-based technologies and offers strategies to improve their functionality. Future research directions, including artificial intelligence (AI)-driven optimization, are also discussed.
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