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Updated: Sep 17, 2025

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
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Hemostasis in primary care: A primer

Kevin E Todd1

  • 1Department of Pediatric Hematology/Oncology, Children's Hospital of the King's Daughters, Norfolk, VA, USA.

Current Problems in Pediatric and Adolescent Health Care
|July 1, 2025
PubMed

Insights

Evaluating pediatric bleeding symptoms requires careful assessment of family history and bleeding severity. Early diagnosis of bleeding disorders like von Willebrand disease is crucial for effective treatment.

Area of Science:

  • Pediatric Hematology
  • Clinical Diagnostics

Background:

  • Bleeding symptoms in children cause significant concern for families and pediatricians.
  • Diagnosing pediatric bleeding disorders presents complexities due to varied clinical presentations and testing nuances.

Purpose of the Study:

  • To guide primary care providers in evaluating children with bleeding symptoms.
  • To review diagnostic complexities, testing, and common bleeding diatheses in pediatrics.

Main Methods:

  • Meticulous patient evaluation including family history, medication review, and bleeding severity assessment.
  • Recommended screening tests: complete blood count with blood smear, activated partial thromboplastin time (aPTT), prothrombin time (PT), von Willebrand factor (VWF) antigen and activity, and fibrinogen level.

Main Results:

  • The incidence of bleeding disorders in referred pediatric patients with bleeding symptoms and abnormal hemostatic screening varies (4-11%).
  • Common pediatric bleeding disorders include factor deficiencies (e.g., von Willebrand disease) and platelet disorders.

Conclusions:

  • A thorough initial evaluation is essential for identifying potential bleeding disorders in children.
  • A collaborative approach between primary care providers and hematologists is paramount for optimal patient outcomes.

Keywords:
Bleeding DisorderHemostasisPediatricPrimary Care

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