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Updated: Sep 17, 2025

Functional Characterization of RING-Type E3 Ubiquitin Ligases In Vitro and In Planta
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Published on: December 5, 2019

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Functional characterisation of components in two Plasmodium falciparum Cullin-RING-Ligase complexes

Danushka Marapana1,2, Simon A Cobbold3,4, Michal Pasternak3,4

  • 1The Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Australia. marapana@wehi.edu.au.

Scientific Reports
|July 1, 2025
PubMed
Summary

The study characterizes Plasmodium falciparum Cullin-RING-Ligase (CRL) complexes, revealing their essential roles in parasite DNA replication and inner-membrane biogenesis. These findings highlight the importance of ubiquitination pathways in malaria parasite survival.

Keywords:
P. falciparumCullin-ring-ligaseE3 ligaseMalariaUbiquitination

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