Sex-based differences in the predictive significance of the waist circumference glucose index for future diabetes risk
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View abstract on PubMed
Summary
This summary is machine-generated.The waist circumference-glucose index (WyG) effectively predicts diabetes risk in Japanese adults. This study found WyG is a reliable diabetes predictor, with performance varying between sexes.
Area Of Science
- Endocrinology
- Metabolic Disorders
- Public Health
Background
- Diabetes mellitus is a significant global health issue.
- The waist circumference-glucose index (WyG) is a known diabetes predictor.
- WyG's utility and sex-specific differences in Japanese populations are not well-understood.
Purpose Of The Study
- To assess the dynamic prediction capability of WyG for diabetes in Japanese adults.
- To investigate potential sex-specific differences in WyG's predictive performance.
- To identify sex-specific thresholds for WyG.
Main Methods
- Analysis of data from 15,464 Japanese adults without prior diabetes.
- Multivariate Cox regression and time-dependent ROC curve analysis.
- Sex-based subgroup analyses and sensitivity analyses, including E-value calculations.
Main Results
- WyG showed a significant association with diabetes in both men and women.
- Predictive performance varied by sex, with different influencing factors (age, fatty liver in men).
- Sex-specific thresholds were identified (WyG > 8.19 for women, > 8.32 for men).
Conclusions
- WyG is a reliable predictor of diabetes in the Japanese population.
- The predictive performance of WyG for diabetes differs between sexes.
- Sex-specific thresholds can enhance WyG's clinical utility for diabetes risk assessment.
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