Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

495
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
495
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

44
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
44
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

54
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
54
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

20
A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
20
Dementia l: Introduction01:22

Dementia l: Introduction

35
Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
35

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Accurate weed detection in UAV grassland images via intelligent annotation and multi-dimensional network enhancement.

Frontiers in plant science·2026
Same author

Rapid Diversification of a Natural Heterosigma akashiwo Virus Population during a Host Bloom.

Microbes and environments·2026
Same author

Navigating Inner Helmholtz Plane Reactions Enables Robust Lithium Metal Anodes for 500 Wh kg<sup>-1</sup> Pouch Cells.

Journal of the American Chemical Society·2026
Same author

Pathological complete response to perioperative treatment with darolutamide plus ADT in locally advanced prostate cancer without PTEN or RB1 loss: a case report.

Frontiers in pharmacology·2026
Same author

Non-linear saturation threshold of gonadotropin dose on cumulative live birth rates in advanced-age women with polycystic ovary syndrome: a retrospective cohort study.

Frontiers in endocrinology·2026
Same author

<i>Operando</i> Nanoscale Measurements of Electrochemical Interfaces: Emerging Frontiers of Scanning Electrochemical Cell Microscopy.

Analytical chemistry·2026

Related Experiment Video

Updated: May 5, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

3.1K

Serum multi-trace elements and post-stroke cognitive impairment: a prospective observational cohort study.

Ruolin Zhou1,2, Weijie Zhai1,2, Lingjie Meng1,2

  • 1Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin University, Changchun, China.

Translational Psychiatry
|July 2, 2025
PubMed
Summary

Serum iron, zinc, magnesium, and copper levels impact post-stroke cognitive impairment (PSCI) risk. Maintaining optimal levels of these trace elements may help reduce PSCI incidence and progression in stroke survivors.

More Related Videos

Motor Dual-Tasks for Gait Analysis and Evaluation in Post-Stroke Patients
05:23

Motor Dual-Tasks for Gait Analysis and Evaluation in Post-Stroke Patients

Published on: March 11, 2021

2.5K
Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients
07:42

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients

Published on: December 16, 2022

3.1K

Related Experiment Videos

Last Updated: May 5, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

3.1K
Motor Dual-Tasks for Gait Analysis and Evaluation in Post-Stroke Patients
05:23

Motor Dual-Tasks for Gait Analysis and Evaluation in Post-Stroke Patients

Published on: March 11, 2021

2.5K
Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients
07:42

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients

Published on: December 16, 2022

3.1K

Area of Science:

  • Neurology
  • Biochemistry
  • Nutritional Science

Background:

  • Post-stroke cognitive impairment (PSCI) is a common and debilitating condition affecting stroke survivors.
  • Identifying modifiable risk factors is crucial for mitigating PSCI.
  • Serum multi-trace elements are vital for neurological function but their role in PSCI is not fully understood.

Purpose of the Study:

  • To investigate the association between baseline serum multi-trace element concentrations and the incidence of PSCI.
  • To explore the relationship between specific multi-trace elements and different cognitive domains.
  • To assess the predictive value of serum multi-trace elements for PSCI risk.

Main Methods:

  • Logistic regression analyses were used to examine the association between serum multi-trace elements and PSCI.
  • The Kruskal-Wallis test was employed to assess associations with specific cognitive domains.
  • The Montreal Cognitive Assessment was used to define PSCI.
  • Predictive ability was evaluated by assessing improvements in risk reclassification.

Main Results:

  • Lower serum iron and zinc concentrations were linked to a higher risk of PSCI.
  • Higher serum iron and magnesium, and lower serum copper concentrations were associated with a lower risk of PSCI.
  • Serum iron influenced broader cognitive functions, while magnesium and copper were strongly linked to language and executive functions.
  • Inclusion of multi-trace elements improved PSCI risk prediction.

Conclusions:

  • Serum multi-trace elements, including iron, zinc, magnesium, and copper, are significantly associated with the risk and progression of PSCI.
  • Specific trace elements have differential impacts on various cognitive domains.
  • Monitoring and potentially modulating serum multi-trace element levels could be a viable strategy for preventing or managing PSCI in stroke survivors.