Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

173
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
173
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

225
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
225
Depression: Overview01:18

Depression: Overview

361
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
361

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A dual-pathway dysregulation in prefrontal-habenular circuits mediates stress susceptibility.

Nature communications·2026
Same author

Neurocomputational Mechanisms Linking Future Interaction Prospects to Reactive and Proactive Costly Punishment.

Neuroscience bulletin·2026
Same author

Dual neurocomputational mechanisms underlying intergroup bias in costly punishment.

NeuroImage·2026
Same author

Bright light therapy induces insular frequency-specific functional plasticity in young adults with subthreshold depression: A randomized, double-blind, placebocontrolled study.

Neural regeneration research·2026
Same author

The self-interest of adolescents overrules cooperation in social dilemmas.

eLife·2026
Same author

The effect of intranasal oxytocin on the neuropsychological substrates of intergroup categorization.

Brain imaging and behavior·2026

Related Experiment Video

Updated: Sep 17, 2025

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
08:42

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Published on: May 19, 2015

10.9K

Reduced neural suppression at occipital cortex in subthreshold depression.

Jinhui Li1, Yuheng Tan1, Zixin Zheng2,3

  • 1Division of Medical Psychology and Behavior Science, School of Medicine, Jinan University, Guangzhou, China.

Translational Psychiatry
|July 2, 2025
PubMed
Summary

Young adults with subthreshold depression (SD) show impaired visual perception and reduced neural suppression in key brain areas. This suggests early occipital cortex changes may precede major depression, aiding in early detection.

More Related Videos

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
05:19

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Published on: July 7, 2023

2.5K
Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method
07:12

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

3.7K

Related Experiment Videos

Last Updated: Sep 17, 2025

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
08:42

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Published on: May 19, 2015

10.9K
Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
05:19

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Published on: July 7, 2023

2.5K
Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method
07:12

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

3.7K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Visual Perception

Background:

  • Major depression is linked to visual perception deficits and occipital cortex changes.
  • It is unclear if these abnormalities occur in subthreshold depression (SD), a precursor to major depression.

Purpose of the Study:

  • To investigate visual perception and neural activity in young adults with SD compared to healthy controls (HC).
  • To explore the neural basis of visual processing abnormalities in early-stage depression.

Main Methods:

  • Experiment 1: Psychophysical tasks in 95 young adults with SD and HC.
  • Experiment 2: Functional magnetic resonance imaging (fMRI) in 63 young adults with SD and HC.

Main Results:

  • SD group exhibited impaired behavioral spatial suppression.
  • Reduced neural suppression was observed in the human middle temporal complex (hMT+) and early visual cortex (EVC) in the SD group.
  • Enhanced functional connectivity between hMT+ and prefrontal cortex, insula, and postcentral gyrus was found in the SD group.

Conclusions:

  • Visual perception and neural suppression deficits in the occipital cortex are present in early-stage depression (SD).
  • Altered functional connectivity patterns are associated with SD.
  • Findings highlight the occipital cortex's role in the early identification and prevention of depression.