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Updated: Sep 17, 2025

Protocols for Analyzing the Role of Paneth Cells in Regenerating the Murine Intestine using Conditional Cre-lox Mouse Models
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Published on: November 21, 2015

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Lipoic acid functions in Paneth cells to prevent human intestinal stem cell aging

Zehong Zhang1,2, Qianyi Wan1,3, Yuedan Zhu1

  • 1West China Centre of Excellence for Pancreatitis and Laboratory of Metabolism and Aging, Frontiers Science Center for Disease-related Molecular Network and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.

Nature Communications
|July 2, 2025
PubMed
Summary

Alpha-lipoic acid (ALA) supplementation combats intestinal stem cell (ISC) aging by restoring Paneth cell function. This finding offers a potential therapeutic strategy for age-related intestinal decline.

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