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Updated: Sep 17, 2025
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A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
Published on: February 27, 2018
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Developed a knowledge base of risk factors for postoperative cognitive dysfunction: a retrospective database study
Na Tang1,2, Jianchao Duan1,3,4, Xingyun Liu5,6
1Department of Anesthesiology, West China Hospital, Sichuan university, No. 37th, Guoxue Alley, Wuhou District, Chengdu, 610041, Sichuan, China.
Scientific Reports
|July 2, 2025
Summary
Identifying risk factors for postoperative cognitive dysfunction (POCD) is crucial for patient care. This study created a comprehensive knowledge base from thousands of studies to aid in personalized treatment and future research.
Area of Science:
- Neuroscience
- Medical Informatics
- Clinical Research
Background:
- Postoperative cognitive dysfunction (POCD) is a significant clinical issue linked to adverse outcomes.
- Current research on POCD risk factors is fragmented, hindering effective management strategies.
Purpose of the Study:
- To create the first comprehensive knowledge base of multidimensional risk factors for POCD.
- To support personalized perioperative care and standardize data for future mechanistic studies.
Main Methods:
- Systematic analysis of 2,837 PubMed-indexed clinical studies published between 1991 and May 2024.
- Extraction and manual curation of 860 distinct predictive risk factors using a multidisciplinary expert panel protocol.
- Development of a hierarchical visualization framework for risk factors across demographic, clinical, anesthetic, surgical, and biomarker domains.
Main Results:
- A curated knowledge base (POCDKB) integrating a wide array of POCD risk factors was established.
- The POCDKB enables visualization of risk factor hierarchies across multiple domains.
- The database serves as a dynamic platform for continuous evidence updates and collaborative data sharing.
Conclusions:
- The POCDKB provides essential decision support for clinicians in managing POCD.
- This resource facilitates standardized data parameters for advancing POCD mechanistic investigations.
- The platform aims to drive innovation in POCD research and therapeutic strategies.
