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Left atrioventricular coupling index measured by echocardiography in heart failure with preserved ejection fraction

Hai Nguyen Ngoc Dang1, Thang Viet Luong2, Hung Khanh Tran2

  • 1Faculty of Medicine, Duy Tan University, Da Nang, 550000, Vietnam.

Scientific Reports
|July 2, 2025
PubMed

Insights

The left atrioventricular coupling index (LACI) shows promise as an accessible echocardiographic marker for early heart failure (HF) detection. This study found LACI significantly elevated in HF patients, particularly those with HFpEF, indicating its diagnostic potential.

Area of Science:

  • Cardiology
  • Echocardiography
  • Heart Failure Diagnostics

Background:

  • Heart failure (HF) presents a significant global health challenge, necessitating improved diagnostic tools.
  • Current noninvasive imaging often focuses on individual heart chambers (left atrium/left ventricle), potentially missing crucial inter-chamber dynamics.

Purpose of the Study:

  • To evaluate the left atrioventricular coupling index (LACI) as an early diagnostic marker for heart failure (HF).
  • To assess the diagnostic performance of LACI in distinguishing HF patients, particularly those with HFpEF, from healthy controls and HFrEF patients.

Main Methods:

  • A cross-sectional study involving 160 participants (60 HF patients) from Vietnam.
  • Echocardiographic assessment to calculate the LACI.
  • Statistical analysis, including multivariate analysis, to determine LACI's predictive value.

Main Results:

  • LACI levels were significantly higher in HF patients compared to controls (59.16±17.94% vs. 13.15±3.92%).
  • LACI showed a strong diagnostic performance for HFpEF (AUC 0.951), with an optimal threshold of 33.07.
  • LACI was identified as an independent predictor of HFpEF.

Conclusions:

  • The left atrioventricular coupling index (LACI) is a valuable and accessible echocardiographic parameter for diagnosing heart failure, especially HFpEF.
  • LACI's ability to reflect physiological connections between heart chambers offers a promising approach for early HF detection.

Keywords:
EchocardiographyHeart failure with preserved ejection fractionHeart failure with reduced ejection fractionLeft atrioventricular coupling index

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