Association of miR-938 rs2505901 T > C polymorphism with reduced risk of venous malformations in a Chinese population

Venous malformations are a common congenital vascular disorder. MicroRNAs are micro non-coding RNAs that are responsible for regulating the expression of genes after transcription. This study aimed to investigate the relationship between miR-938 rs2505901 T > C polymorphism and venous malformations. We collected blood samples from 1,113 patients with venous malformations and 1,158 members of the control group. TaqMan genotyping of miR-938 rs2505901 T > C was performed by real-time fluorescence quantitative polymerase chain reaction. We found the miR-938 rs2505901 T > C polymorphism was significantly associated with reduced risk of venous malformations in children [CC vs. TT: adjusted OR = 0.56, 95% confidence interval (CI) = 0.33-0.94, P = 0.027; CC vs. TT/TC: adjusted OR = 0.56, 95% CI = 0.33-0.93, P = 0.026]. We categorized venous malformations into six subtypes: head, neck, trunk, upper extremity, lower extremity, and multisite. Stratified analysis of rs2505901 T > C and venous malformations at different sites showed that the rs2505901 T > C polymorphism was significantly associated with a reduced risk of venous malformations occurring in the head. [Crude OR = 0.37, 95% CI = 0.17-0.82, P = 0.014; adjusted OR = 0.40, 95% CI = 0.17-0.92, P = 0.031]. The miR-938 rs2505901 T > C polymorphism was significantly associated with a reduced risk of venous malformations in children, and rs2505901 T > C was significantly associated with a reduced risk of venous malformations occurring in the head; the underlying mechanisms of venous malformations still need to be further study.