Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Duodenitis: a clinical, endoscopic and histopathologic study.

The Quarterly Journal of Medicine

|September 1, 1985

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Neurological Sequelæ in Repatriated Prisoners of War from Hong Kong: A Follow-up [Abstract].

Proceedings of the Royal Society of Medicine·2009

Same author

Milestones in the evolution of endoscopy: a short history.

The journal of the Royal College of Physicians of Edinburgh·2003

Same author

Ileal reservoir after colectomy and mucosal proctectomy for chronic ulcerative colitis and dysplasia.

Journal of the Royal College of Surgeons of Edinburgh·1987

Same author

Mucosal proctectomy and colo-anal anastomosis for distal ulcerative proctocolitis.

The British journal of surgery·1987

Same author

Chronic inflammatory bowel disease, cigarette smoking and use of oral contraceptives.

British medical journal (Clinical research ed.)·1986

Same author

Intrapleural perforation of peptic ulcer in association with diaphragmatic hernia.

British journal of diseases of the chest·1985

Same journal

Megaloblastic anaemia of pregnancy and the puerperium; a review of forty-five cases with special reference to their response to treatment.

The Quarterly journal of medicine·2014

Same journal

Carcinoma of the bronchus; a clinical and pathological survey of 866 cases.

The Quarterly journal of medicine·2014

Same journal

Heart failure in acute nephritis.

The Quarterly journal of medicine·2014

Same journal

Uraemia complicating low salt treatment of heart failure.

The Quarterly journal of medicine·2014

Same journal

The effect of tobacco on lung-volume.

The Quarterly journal of medicine·2014

Same journal

Chronic monocytic leukaemia.

The Quarterly journal of medicine·2014

See all related articles

Serial endoscopies in 219 dyspepsia patients show that duodenitis often precedes ulcers, with 81.8% developing ulcers over 36 months. Cimetidine healed ulcers but not duodenitis in most cases.

Area of Science:

Gastroenterology
Internal Medicine
Digestive Diseases

Background:

Dyspepsia is a common condition with varied endoscopic findings.
Understanding the natural history of duodenitis and its relationship with peptic ulcers is crucial for patient management.

Purpose of the Study:

To investigate the natural progression of duodenitis and ulcer formation in patients with dyspepsia using serial endoscopies.
To assess the impact of cimetidine treatment on both ulcer healing and duodenitis resolution.

Main Methods:

A cohort of 219 dyspepsia patients underwent serial endoscopies and mucosal biopsies over 3 to 36 months.
Maximal acid output was measured in 135 subjects.
Treatment with cimetidine was administered to 163 subjects.

Related Experiment Videos

Main Results:

By the final endoscopy, 81.8% of subjects showed evidence of an ulcer crater.
Erosive duodenitis was more common than non-erosive duodenitis and significantly associated with higher acid output.
Cimetidine healed ulcers in 68.5% of patients, but only resolved duodenitis in 28.1%.

Conclusions:

Duodenitis, particularly erosive duodenitis, frequently precedes ulcer development in dyspepsia patients.
Serial endoscopic monitoring is valuable for understanding the dynamic relationship between duodenitis and ulcers.
Cimetidine is effective for ulcer healing but has limited efficacy in resolving underlying duodenitis.