Lablab purpureus phytochemicals demonstrate potential anticancer activity as evidenced through experimental and...

Area of Science:

• Phytochemistry
• Pharmacology
• Computational Biology

Background:

• Lablab purpureus seeds are traditionally used for medicinal purposes.
• The seeds possess rich phytochemicals with potential health benefits.

Purpose of the Study:

• To investigate the antioxidant, anti-inflammatory, and cytotoxic properties of Lablab purpureus seed extract.
• To identify potential anticancer compounds through in silico analysis.

Main Methods:

• In vitro antioxidant, anti-inflammatory, and cytotoxic assays.
• Gas Chromatography-Mass Spectrometry (GC-MS) for compound identification.
• Molecular docking and dynamics simulations against cancer-related proteins.

Main Results:

• The methanolic extract demonstrated significant antioxidant, anti-inflammatory, and cytotoxic effects on cancer cell lines (MCF-7, A549).
• Minimal cytotoxicity was observed in normal HEK-293 cells.
• In silico studies identified stable interactions between specific seed compounds and cancer-associated proteins (CCNB1, CDC20, CCNA2).

Conclusions:

• Lablab purpureus seed extract possesses promising therapeutic potential.
• Identified compounds show potential as anti-breast and anti-lung cancer agents.