Related Experiment Video

Updated: Sep 17, 2025

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

13.8K

The biogenesis and biological roles of migrasomes in human diseases

Yifan Zhang1, Wei Chen1, Jiageng Zhu2

  • 1Department of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.

Cell Death Discovery
|July 2, 2025
PubMed

Insights

Migrasomes are novel vesicles from migrating cells, crucial for cell communication and tissue repair. These structures offer potential for treating diseases like cancer and neurodegeneration.

Area of Science:

  • Cell Biology
  • Extracellular Vesicles
  • Cell Migration

Background:

  • Migrasomes are newly discovered extracellular vesicles produced by migrating cells.
  • These pomegranate-shaped organelles are released from the cell's trailing edge.
  • They are vital for cell-to-cell communication, signaling, and tissue remodeling.

Purpose of the Study:

  • To provide an in-depth analysis of migrasome biogenesis, structure, and molecular makeup.
  • To explore the emerging roles of migrasomes in various physiological and pathological processes.
  • To discuss challenges and future clinical applications of migrasome research.

Main Methods:

  • Literature review of recent studies on migrasomes.
  • Analysis of migrasome biogenesis and molecular packaging.
  • Exploration of migrasome involvement in disease pathogenesis.

Main Results:

  • Migrasomes selectively package proteins, lipids, and RNA for intercellular communication (migracytosis).
  • They are implicated in immune responses, cancer metastasis, tissue repair, and development.
  • Emerging evidence links migrasomes to cancer, neurodegenerative diseases, and immune modulation.

Conclusions:

  • Migrasomes represent a significant discovery in cell biology with diverse functional roles.
  • Further research into migrasomes is essential for understanding their full potential in health and disease.
  • Migrasomes hold promise for future clinical applications in disease treatment and management.

More Related Videos

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum10:22

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Published on: December 4, 2015

9.0K
Evaluation of Extracellular Vesicle Function During Malaria Infection13:45

Evaluation of Extracellular Vesicle Function During Malaria Infection

Published on: February 14, 2018

7.8K

Related Concept Videos

Role of Myosin in Cell Migration01:18

Role of Myosin in Cell Migration

Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II  is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
2.5K
Intralumenal Vesicles and Multivesicular Bodies01:38

Intralumenal Vesicles and Multivesicular Bodies

Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
3.7K
Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
5.2K
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
4.9K
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
2.4K
Fluid Mosaic Model01:19

Fluid Mosaic Model

Scientists identified the plasma membrane in the 1890s and its principal chemical components (lipids and proteins) by 1915. The model for plasma membrane structure, proposed in 1935 by Hugh Davson and James Danielli, was the first model to be widely accepted in the scientific community. The model was based on the plasma membrane's "railroad track" appearance in early electron micrographs. Davson and Danielli theorized that the plasma membrane's structure resembled a sandwich...
13.0K