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Risk factors and reasons for romosozumab nonadherence in a case-control study
Ting-Chien Tsai1, Yun-Shan Yen2, Chang-Hao Lin1
1Department of Orthopaedics, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi, Taiwan.
Scientific Reports
|July 2, 2025
Summary
Male patients and those self-paying for medication face higher risks of romosozumab nonadherence. Patient-related factors are the primary reasons for missed osteoporosis treatment injections.
Area of Science:
- Osteoporosis Management
- Pharmacotherapy Adherence
- Patient Outcomes
Background:
- Romosozumab is a critical treatment for osteoporosis.
- Understanding nonadherence to romosozumab therapy is essential for improving patient outcomes.
- Risk factors and reasons for romosozumab nonadherence are not well-defined.
Purpose of the Study:
- To compare patients adherent to romosozumab therapy with those who were nonadherent.
- To identify potential risk factors associated with romosozumab nonadherence.
- To explore the primary reasons for treatment nonadherence in osteoporosis patients.
Main Methods:
- A case-control study design was employed.
- Patients receiving romosozumab between February 2022 and March 2024 were analyzed.
- Univariate and logistic regression analyses identified associations between patient characteristics and nonadherence.
Main Results:
- Male patients exhibited a significantly higher risk of nonadherence (9.03-fold).
- Self-payment for romosozumab was linked to increased nonadherence risk (2.756-fold).
- Patient-related factors (87.0%) were the predominant reasons for nonadherence, followed by medicine-related (8.7%) and health system-related factors (4.3%).
Conclusions:
- Male sex and self-payment are identified risk factors for romosozumab nonadherence.
- Patient-related factors are the leading cause of nonadherence to osteoporosis treatment.
- Findings can inform healthcare providers in developing targeted interventions to improve adherence.
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