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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Pulmonary Function Tests01:25

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Pulmonary Function Tests (PFTs)
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
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Related Experiment Video

Updated: Sep 17, 2025

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
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Relationship between intraocular pressure and pulmonary function.

Ryo Terauchi1, Kota Fukai2, Shota Fujimoto3

  • 1Department of Ophthalmology, The Jikei University School of Medicine, 3- 25-8 Nishi-shinbashi, Minato-ku, Tokyo, 105-8461, Japan. r.terauchi0813@gmail.com.

Scientific Reports
|July 2, 2025
PubMed
Summary
This summary is machine-generated.

This study found a positive link between respiratory function, specifically the FEV1/FVC ratio, and intraocular pressure (IOP). Lower IOP was observed in individuals with obstructive ventilatory disorders, highlighting the importance of respiratory health in managing eye pressure.

Keywords:
Big dataForced expiratory volume in 1 secondForced vital capacityIntraocular pressureObstructive ventilatory disorderSpirometry

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Area of Science:

  • Ophthalmology
  • Pulmonology
  • Public Health

Background:

  • Intraocular pressure (IOP) is a key risk factor for glaucoma.
  • Respiratory function, particularly obstructive ventilatory disorders, has been an under-explored area in relation to IOP.
  • Understanding potential links can inform comprehensive health management strategies.

Purpose of the Study:

  • To investigate the association between key respiratory function indices and intraocular pressure (IOP).
  • To explore if spirometry measures correlate with IOP levels in large population datasets.
  • To determine the clinical relevance of respiratory function in the context of IOP management.

Main Methods:

  • Analysis of two large datasets (Jikei and JNDS) comprising over 290,000 participants.
  • Assessment of respiratory function using spirometry, focusing on FEV1/FVC ratio, ppFEV1, and ppFVC.
  • Statistical analysis using multiple linear regression to evaluate the relationship between respiratory parameters and IOP.

Main Results:

  • A significant positive linear correlation was found between the FEV1/FVC ratio and IOP in both datasets.
  • Participants with lower FEV1/FVC ratios (indicative of obstructive disorders) exhibited significantly lower IOP.
  • Percent predicted FEV1 (ppFEV1) and FVC (ppFVC) showed no significant association with IOP.

Conclusions:

  • The FEV1/FVC ratio, a marker of obstructive ventilatory disorders, is positively associated with intraocular pressure.
  • Lower IOP may be observed in individuals with reduced FEV1/FVC ratios.
  • Respiratory function assessment may offer insights for comprehensive IOP management strategies.