Predictive value of AMH in late reproductive age: a retrospective cohort study

This study evaluates the predictive value of Anti-Müllerian Hormone (AMH) levels on outcomes in medically assisted reproduction (MAR), with a focus on women of late reproductive age. AMH, produced by granulosa cells in ovarian follicles, serves as an important indicator of ovarian reserve. A retrospective cohort analysis was conducted, encompassing 4891 MAR cycles, to assess the age-specific predictive value of AMH for clinical pregnancy. The results indicate that AMH is significantly correlated with clinical pregnancy outcomes (p < 0.01) and demonstrates potential predictive value in women over 35 years of age, with its predictive capacity increasing notably with age (AUC = 0.62-0.69). However, in younger women, the correlation between AMH levels and MAR outcomes is weaker (AUC = 0.48-0.53). These findings highlight the importance of integrating AMH measurements with age when assessing fertility potential and tailoring MAR treatments, particularly for women approaching the end of their reproductive lifespan.