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Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis

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Brain functional connectivity after Stroop task induced cognitive fatigue.

Jilin Wu¹, Zhongtian Guan^2,3, Chunlin Li^2,3

¹Beijing Rehabilitation Hospital, Beijing Rehabilitation Medicine Academy, Capital Medical University, Beijing, China.

Scientific Reports

|July 2, 2025

Summary

This summary is machine-generated.

Cognitive fatigue alters brain connectivity, particularly in the thalamus and Front-Parietal network, impacting cognitive function. Understanding these neural changes aids in developing strategies for cognitive enhancement and rehabilitation.

Keywords:

Cognitive fatigue EEG Functional connectivity Stroop VAS-F fMRI

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Area of Science:

Neuroscience
Cognitive Science
Medical Imaging

Background:

Cognitive fatigue affects daily activities and cognitive performance.
Understanding the neural underpinnings of cognitive fatigue is crucial for developing interventions.

Purpose of the Study:

To investigate whole-brain functional connectivity changes induced by cognitive fatigue.
To identify neural mechanisms underlying cognitive fatigue in healthy adults.
To provide a basis for enhancing cognitive activities and rehabilitation.

Main Methods:

fMRI was used to analyze Amplitude of Low-Frequency Fluctuations (ALFF), Regional Homogeneity (ReHo), Functional Connectivity (FC), and graph theory metrics.
48 healthy adults (20-35 years) underwent assessments before and after a cognitive fatigue task.
Correlations between brain activity changes and subjective fatigue levels were examined.

Main Results:

Changes in the bilateral thalamus and Front-Parietal network activity correlated significantly with subjective fatigue.
The left precuneus, cerebellum, and frontal regions showed altered activity patterns related to cognitive fatigue.
Distinct patterns of functional connectivity alterations were observed post-fatigue.

Conclusions:

Cognitive fatigue is associated with specific alterations in whole-brain functional connectivity.
The thalamus and Front-Parietal network play a key role in the neural regulation of cognitive fatigue.
Findings support the development of targeted interventions for cognitive fatigue and rehabilitation.