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Monthly changes in the effect of BCG on the migration of polymorphonuclear leucocytes
Research Communications in Chemical Pathology and Pharmacology
|August 1, 1985
Abstract:
Monthly changes in the migration of polymorphonuclear leucocytes (PMN) produced by subcutaneous implantation of BCG-impregnated rayone-made disks was examined over a period of 15 months. In experiments carried out at 90h00, the highest PMN count of 40.2 +/- 8.4 PMN/10,000 micrometers2 10,000 micrometers2 was obtained in April. Mechanisms that could explain the circannual variation are suggested.
Insights
Polymorphonuclear leucocyte (PMN) migration shows seasonal changes, peaking in April. This study examined monthly PMN counts over 15 months to understand these immune system variations.
Area of Science:
- Immunology
- Cell Biology
- Chronobiology
Background:
- Subcutaneous implantation of BCG-impregnated disks stimulates immune cell migration.
- Polymorphonuclear leucocytes (PMN) are key immune cells involved in inflammatory responses.
Purpose of the Study:
- To investigate monthly variations in PMN migration.
- To identify potential circannual patterns in immune cell activity.
Main Methods:
- Monthly monitoring of PMN migration over 15 months.
- Quantification of PMN counts using microscopy (PMN/10,000 micrometers2).
Main Results:
- A significant peak in PMN count (40.2 +/- 8.4 PMN/10,000 micrometers2) was observed in April.
- Data suggests a circannual rhythm in PMN migration patterns.
Conclusions:
- PMN migration exhibits seasonal fluctuations.
- Further research is needed to elucidate the mechanisms driving these circannual variations in immune response.