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Published on: May 30, 2025
653
Liver-specific lncRNAs associated with liver cancers.
Olga Y Burenina1,2,3, Roman K Makarchenko2, Maria P Rubtsova2,3
1Center of Molecular and Cellular Biology, Moscow, Russia.
FEBS Open Bio
|July 2, 2025
Summary
This review highlights novel long non-coding RNAs (lncRNAs) preferentially expressed in liver tumors. These specific lncRNAs show potential as valuable biomarkers for improved liver cancer diagnostics and prognosis.
Area of Science:
- Molecular Biology
- Genomics
- Cancer Research
Background:
- Long non-coding RNAs (lncRNAs) are RNA molecules longer than 200 nucleotides that do not encode proteins.
- lncRNAs exhibit high tissue specificity and play crucial roles in gene regulation.
- Altered lncRNA expression is linked to various diseases, including cancer, making them potential biomarkers.
Purpose of the Study:
- To review lncRNAs with preferential expression in liver and liver tumors.
- To explore the dysregulation of these lncRNAs in liver malignancies.
- To assess their significance as potential biomarkers for liver cancer.
Main Methods:
- Literature review of recent discoveries on lncRNAs in liver cancer.
- Analysis of studies reporting dysregulated lncRNA expression in liver tumors.
- Examination of cellular mechanisms involving specific lncRNAs.
Main Results:
- Several lncRNAs, including LINC01554, LINC01093, LINC01348, LINC02428, and FAM99B, show preferential expression in liver and/or liver tumors.
- These lncRNAs are frequently dysregulated in liver malignancies.
- Their altered expression is associated with specific cellular mechanisms relevant to liver cancer development.
Conclusions:
- lncRNAs with preferential liver expression represent promising biomarkers for liver cancer.
- Further research into these specific lncRNAs can enhance diagnostic and prognostic capabilities for liver malignancies.
- Clinical tests incorporating these novel biomarkers could significantly improve liver cancer management.
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