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Microbiome-based therapeutics towards healthier aging and longevity
Saurabh Kadyan1,2,3, Gwoncheol Park1,2, Tejinder P Singh4
1The Gut Biome Lab, Florida State University, Tallahassee, FL, 32306, USA.
Genome Medicine
|July 2, 2025
Summary
The gut microbiome influences aging and longevity. Targeting the gut microbiome offers a promising strategy to prevent and treat age-related diseases, promoting health in older adults.
Area of Science:
- Microbiology
- Gerontology
- Immunology
Background:
- The gut microbiome plays a crucial role in human health from birth throughout the lifespan.
- Microbiome composition undergoes age-related changes, impacting physiological and immunological development.
- Emerging research links the gut microbiome to healthy aging and longevity.
Purpose of the Study:
- To provide a comprehensive overview of the gut microbiome's connection to human aging.
- To explore the interplay between the microbiome, aging, and age-related diseases.
- To discuss the potential of microbiome-based therapeutics for aging populations.
Main Methods:
- Literature review and synthesis of current research on the gut microbiome and aging.
- Analysis of the association between microbiome alterations and age-related conditions.
- Exploration of emerging and potential microbiome-based therapeutic strategies.
Main Results:
- The gut microbiome is closely associated with healthy aging and disease-free longevity.
- Microbiome-targeted interventions show promise for preventing and managing aging-related disorders.
- Tailored microbiome therapeutics could enhance healthspan and well-being in the elderly.
Conclusions:
- The gut microbiome is a critical factor in the aging process and overall health.
- Targeting the gut microbiome represents a significant therapeutic opportunity for age-related diseases.
- Future development of elderly-specific microbiome therapies holds promise for promoting health and longevity.
Keywords:
DysbiosisGeriatricsGutInflammagingMetagenomicsMicrobiotaPostbioticsPrebioticsProbioticsSenescenceMore Related Videos
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