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Related Experiment Videos

Immunochemosurgery for gastric cancer.

J P Kim

    Seminars in Surgical Oncology
    |January 1, 1985
    PubMed
    Summary

    Immunochemotherapy combined with surgery significantly improves survival rates for stage III gastric cancer patients. This combined approach demonstrated a 15% increase in survival compared to surgery alone, with enhanced immune function observed.

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    A Clinicopathological Analysis of Recurrent Gastric Cancer.

    Cancer research and treatment·2015

    Area of Science:

    • Oncology
    • Immunology
    • Surgical Oncology

    Background:

    • Gastric cancer, particularly stage III, presents significant treatment challenges.
    • Optimizing survival rates beyond radical surgery remains a critical goal in gastric cancer management.

    Purpose of the Study:

    • To evaluate the efficacy of combining immunochemotherapy with radical subtotal gastrectomy for stage III gastric cancer.
    • To compare survival outcomes and immune parameters between patients receiving immunochemotherapy plus surgery and those receiving surgery alone.

    Main Methods:

    • A comparative study involving 73 patients treated with radical subtotal gastrectomy and 18 months of immunochemotherapy versus 64 patients treated with radical subtotal gastrectomy alone.
    • Immunochemotherapy included picibanil (Streptococcus pyogenes preparation) for immunotherapy and either MFC or FME regimens for chemotherapy.
    • Immune parameters assessed included DNCB test, T lymphocyte counts, lymphoblastogenesis, and antibody-dependent cellular cytotoxicity (ADCC).

    Main Results:

    • The immunochemotherapy group showed a 5-year survival rate of 38.1% compared to 24.8% in the surgery alone group (p < 0.01).
    • A consistent survival difference of approximately 15% favoring the immunochemotherapy group was observed over 5 years of follow-up.
    • Favorable immune parameter data (DNCB, T cells, lymphoblastogenesis, ADCC) were noted in the immunochemotherapy group.

    Conclusions:

    • Early postoperative immunochemotherapy following radical gastrectomy appears superior to surgery alone for stage III gastric cancer.
    • For stage I and II gastric cancer, radical gastrectomy with 3 months of postoperative immunotherapy is suggested as the optimal treatment.

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