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Updated: Sep 17, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Can we ever have evidence-based decision making in orthopaedics? A qualitative evidence synthesis and conceptual
Arabella Scantlebury1, Katherine Jones2, Joy Adamson3
1Centre for Evidence and Implementation Science, College of Social Sciences, University of Birmingham, Birmingham, B15 2RT, England. a.l.scantlebury@bham.ac.uk.
Background:
The perception and use of scientific evidence in orthopaedic surgical decision-making is variable, and there is considerable variation in practice. A previous conceptual framework described eight different drivers of orthopaedic surgical decision-making: formal codified and managerial knowledge, medical socialisation, cultural, normative and political influence, training and formal education, experiential factors, and individual patient and surgeon factors. This Qualitative Evidence Synthesis (QES) aims to refine the conceptual framework to understand how these drivers of decision-making are applied to orthopaedic surgical work in a dynamic and fluid way.
Methods:
A QES explored how different types of knowledge and evidence inform decision-making to explore why there is so much variation in orthopaedic surgical work. Nine databases were systematically searched from 2014 to 2023. Screening was undertaken independently by two researchers. Data extraction and quality assessment were undertaken by one researcher and accuracy checked by another. Findings were mapped to the conceptual framework and expanded through thematic synthesis.
Results:
Twenty-five studies were included. Our re-conceptualised framework of evidence-based orthopaedics portrays how surgeons undergo a constant process of medical brokering to make decisions. Routinely standardising, implementing and regulating surgical decision making presents a challenge when the decision-making process is in a constant state of flux. We found that surgeons constantly prioritise drivers of decision-making in a flexible and context-specific manner. We introduce the concept of socialisation in decision making, which describes "the socialisation of factors affecting decision-making. Socialisation is additive to surgeon identity and organisational capacity, which as explanatory linchpins act to mediate our understanding of how and why surgical decision-making varies. Our conceptual framework allows us to rationalise why formal codified knowledge, typically endorsed through clinical guidelines, consistently plays a limited role in orthopaedic decision-making.
Conclusions:
We present a re-conceptualised framework for understanding what drives real world decision-making in orthopaedics. This framework highlights the dynamic and fluid way these drivers of decision-making are applied in orthopaedic surgical work. A shift in orthopaedics is required away from prioritising informal, experiential knowledge first to incorporating evidence-based sources of evidence as essential for decision-making. This paradigm shift, views decision-making as a complex intervention, that requires alternative approaches underpinned by multi-faceted, evidence-based implementation strategies to encourage evidence-based practice.
Registration:
PROSPERO CRD42022311442 CLINICAL TRIAL NUMBER: Not applicable.
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