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Achieving equitable recruitment through inclusive protocol design: lessons learned from the ILANA study.

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Achieving inclusive research recruitment requires intentional design and mandatory targets, not just aspirations. The ILANA study demonstrates how to improve representation in clinical trials and address health inequities.

Keywords:
HIVHealth equityInclusive recruitmentPublic patient involvementRandomised trials

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Area of Science:

  • Clinical Trials
  • Health Equity Research
  • Public Health

Background:

  • Inclusive research is crucial but challenging to achieve in participant recruitment.
  • Recruiting representative samples that mirror disease distribution in populations remains elusive for many trials.
  • Health inequities persist due to underrepresentation in research.

Purpose of the Study:

  • To highlight tangible strategies for inclusive recruitment in clinical trials.
  • To demonstrate how intentional protocol design and delivery can improve sample representation.
  • To offer a proof of concept for conducting more equitable Randomized Controlled Trials (RCTs).

Main Methods:

  • Drawing on experiences from the ILANA (Implementing Long-Acting Novel Antiretrovirals) study.
  • Emphasizing meaningful public involvement throughout the research process.
  • Utilizing existing data to set appropriate recruitment targets.
  • Incorporating targets into analysis plans via pre-specified analyses and qualitative data triangulation.
  • Implementing mandatory recruitment targets rather than aspirational ones.

Main Results:

  • The ILANA study provides a framework for intentional protocol design to achieve inclusive recruitment.
  • Tangible steps, including mandatory targets and public involvement, can significantly improve participant representation.
  • The study offers a proof of concept for equitable RCTs.

Conclusions:

  • Intentional protocol design and mandatory targets are key to achieving inclusive research recruitment.
  • Extrapolating strategies from the ILANA study can help tackle health inequities.
  • Improved representation in trials leads to findings that can benefit all populations.