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Auditory brainstem responses (ABR) in multiple sclerosis.

G Paludetti, F Ottaviani, V Gallai

    Scandinavian Audiology
    |January 1, 1985
    PubMed
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    Auditory Brainstem Response (ABR) testing reveals frequent abnormalities in multiple sclerosis (MS) patients, highlighting its value in detecting demyelinating processes. Separate ear evaluation is crucial due to common unilateral alterations.

    Area of Science:

    • Neuroscience
    • Audiology
    • Neurology

    Background:

    • Multiple Sclerosis (MS) is a demyelinating disease affecting the central nervous system.
    • Auditory pathway involvement is common in MS, but its detection can be challenging.
    • Standard audiological tests may not fully capture subtle neurological changes.

    Purpose of the Study:

    • To evaluate the utility of Auditory Brainstem Response (ABR) testing in detecting demyelinating processes in MS patients.
    • To assess the prevalence and characteristics of ABR abnormalities in different MS classifications.
    • To emphasize the importance of accurate ABR analysis and separate ear evaluation.

    Main Methods:

    • Thirty-two MS patients (21-55 years) underwent pure-tone audiometry and monoaural ABR testing.

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  • McAlpine criteria were used for MS classification ('definite', 'probable', 'possible').
  • Cross-correlation analysis and V wave parameters were assessed, along with test-retest reliability.

    • Main Results:

    • ABR abnormalities were detected in 88% of 'definite', 71% of 'probable', and 64% of 'possible' MS patients' ears.
    • Cross-correlation parameters and V wave characteristics showed the most frequent alterations.
    • Unilateral ABR abnormalities were common, necessitating separate ear evaluation.

    Conclusions:

    • Auditory Brainstem Response (ABR) testing is a highly reliable method for detecting demyelinating processes in MS.
    • ABR is more sensitive than typically reported, especially when analyzing cross-correlation and V wave parameters.
    • Accurate, separate evaluation of each ear's ABR is essential for comprehensive MS assessment.