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Assessing the suitability of formalin-fixed paraffin-embedded (FFPE) tissue for genome-wide association studies

Julian Reingruber1, Maximilian J Krämer1,2, Jessica Bigge1

  • 1Center for Human Genetics, Philipps University Marburg and University Hospital Marburg, Marburg, Germany.

BMC Research Notes
|July 2, 2025
PubMed
Abstract

No abstract available in PubMed .

Keywords:
DNA extractionFFPE tissueGWASGenome-wide genotyping

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

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