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Updated: Sep 17, 2025

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Ten-Eleven Translocation Family Proteins: Structure, Biological Functions, Diseases, and Targeted Therapy

Junzhi Liang1, Xinni Na2, Lingbo Meng1

  • 1Center of Reproductive Medicine Department of Obstetrics and Gynecology Shengjing Hospital of China Medical University Shenyang China.

Medcomm
|July 2, 2025
PubMed

Insights

Ten-eleven translocation (TET) proteins are key epigenetic regulators involved in DNA demethylation. Dysregulation of TET enzymes is linked to various diseases, highlighting their therapeutic potential.

Area of Science:

  • Epigenetics
  • Molecular Biology
  • Biochemistry

Background:

  • Ten-eleven translocation (TET) proteins are dioxygenases crucial for DNA demethylation.
  • TET enzymes sequentially oxidize 5-methylcytosine, influencing gene expression and development.

Purpose of the Study:

  • To provide a comprehensive overview of TET protein mechanisms and biological functions.
  • To highlight the link between TET dysregulation and disease pathogenesis.
  • To explore TET proteins as potential therapeutic targets.

Main Methods:

  • Literature review of TET protein functions.
  • Analysis of molecular mechanisms in TET-mediated DNA demethylation.
  • Review of studies linking TET dysregulation to disease.

Main Results:

  • TET proteins are essential for remodeling the epigenetic landscape.
  • TET dysregulation is implicated in nervous system, immune, metabolic diseases, and cancers.
  • Understanding TET mechanisms provides insights into disease pathogenesis.

Conclusions:

  • TET proteins play a critical role in epigenetic regulation and development.
  • Targeting TET pathways offers a promising therapeutic strategy for various diseases.
  • Further research into TET proteins will aid in designing targeted therapies.
Keywords:
Biological functionsDemethylationDiseasesTen‐eleven translocationTherapeutic strategies

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