[Advances in Multi-omics Analysis of Cervical Cancer]

Cervical cancer (CC), a common malignant tumor afflicting women, poses serious threats to their health. Therefore, it is critical to develop a thorough understanding of the molecular mechanisms underlying the pathogenesis of CC, and to identify new therapeutic targets and methods for early diagnosis. The multi-omics research in tumors, involving proteomics, transcriptomics, genomics, microbiomics, and metabolomic, offers valuable insights. The multi-omics analysis of biological samples from patients with cervical intraepithelial neoplasia (CIN) and CC can help clarify the pathways involved in the pathogenesis and development of CC. Furthermore, multi-omics studies have identified a number of molecules associated with CC, including actin, lumican, family member with sequence similarity 83 (FAM83A), cadherin EGF-LAG seven-pass G-type receptor 3 (CELSR3), and 5,10-methylenetetrahydrofolate reductase (MTHFR), all of which show potential to be used as new biomarkers. These biomarkers will help make early diagnosis, improve the survival and prognosis of CC patients, and ultimately reduce CC incidence and mortality. This review synthesizes current advances in multi-omics research on cervical cancer.