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How Effective are Key Phytocompound Carrying Polysaccharide Nanocarriers as Anti-Breast Cancer Therapy? A
Deena Elsori1, Pratibha Pandey2, Safia Obaidur Rab3
1Faculty of Resilience, Rabdan Academy, Abu Dhabi, United Arab Emirates.
Abstract:
Breast cancer continues to be one of the most perilous diseases globally due to the challenges in identifying cost-effective and targeted targets for effective treatment strategies. In response to these unmet demands, much research has focused on investigating the anti-breast cancer properties of natural compounds due to their multi-target modes of action and favorable safety profiles. Numerous extracts of medicinal plants, essential oils, and natural bioactive substances have exhibited anticancer properties in preclinical breast cancer models. Nonetheless, the clinical utilization of therapies based on natural chemicals is constrained by challenges such as inadequate solubility and permeability. Innovative drug delivery systems utilizing nanoparticles are currently being investigated as adaptable solutions to overcome these limitations. Polysaccharide-based nanoparticles exhibit promising biodegradability and biocompatibility, making them suitable for targeted drug delivery systems among the diverse nanocarrier types. Many polysaccharide nanocarriers, including chitosan, hyaluronic acid, cellulose, starch, and complex polysaccharides, have been shown to enhance the bioavailability and therapeutic effectiveness of phytocompounds. This review examines the anticancer properties of phytocompounds and polysaccharide nanocarriers in breast cancer before focusing on the use of polysaccharide-based nanocarriers to deliver phytocompounds for the treatment of breast cancer.
Insights
Natural compounds show promise against breast cancer, but delivery challenges exist. Polysaccharide nanoparticles offer a solution, enhancing the effectiveness of these natural compounds for breast cancer treatment.
Area of Science:
- Oncology
- Nanotechnology
- Pharmacology
Background:
- Breast cancer remains a significant global health challenge with limited cost-effective treatment options.
- Natural compounds (phytocompounds) exhibit multi-target anticancer properties and favorable safety profiles.
- Clinical application of phytocompounds is hindered by poor solubility and permeability.
Purpose of the Study:
- To review the anticancer properties of phytocompounds and polysaccharide nanocarriers in breast cancer.
- To explore the use of polysaccharide-based nanocarriers for delivering phytocompounds in breast cancer therapy.
Main Methods:
- Review of existing literature on phytocompounds and nanocarriers for breast cancer.
- Focus on polysaccharide-based nanoparticles (chitosan, hyaluronic acid, cellulose, starch) as drug delivery systems.
- Analysis of studies demonstrating enhanced bioavailability and therapeutic efficacy.
Main Results:
- Numerous phytocompounds and medicinal plant extracts show preclinical anticancer activity against breast cancer.
- Polysaccharide nanoparticles demonstrate biodegradability and biocompatibility for targeted drug delivery.
- Polysaccharide nanocarriers effectively improve the bioavailability and therapeutic outcomes of delivered phytocompounds.
Conclusions:
- Polysaccharide-based nanoparticles are a promising platform for overcoming the delivery limitations of natural compounds in breast cancer treatment.
- This approach enhances the therapeutic potential of phytocompounds, offering a viable strategy for more effective breast cancer therapies.
- Further research into polysaccharide-nanoparticle drug delivery systems is warranted for clinical translation.
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