A Comparative Study of Split-Thickness Skin Graft Fixation and Uptake Using Autologous Platelet-Rich Plasma Versus...

Area of Science:

• Regenerative Medicine
• Wound Healing
• Dermatologic Surgery

Background:

• Split-thickness skin grafting (STSG) is crucial for skin defect repair.
• Graft failure remains a significant clinical challenge in reconstructive surgery.
• Autologous platelet-rich plasma (PRP) is explored for its potential to improve STSG outcomes.

Purpose of the Study:

• To evaluate the efficacy of autologous PRP in enhancing STSG fixation and uptake.
• To compare PRP-assisted grafting with conventional fixation methods.
• To assess the impact of PRP on postoperative complications.

Main Methods:

• Prospective comparative study with 104 patients undergoing STSGs.
• Random allocation into two groups: PRP application vs. conventional fixation (staples/sutures).
• Outcomes assessed: immediate adhesion, graft uptake percentage, edema, and hematoma at days 3, 5, and 7.

Main Results:

• PRP group showed significantly higher immediate postoperative adhesion (69.2% vs. 0%, p<0.001).
• Graft uptake was significantly improved in the PRP group on day 3 (96.07% vs. 86.33%, p<0.001) and day 5 (92.7% vs. 79.9%, p<0.001).
• PRP group experienced significantly fewer complications, including edema and hematoma (p<0.001).

Conclusions:

• Autologous PRP significantly enhances STSG fixation, graft uptake, and overall take rates.
• PRP provides immediate graft stability, beneficial for challenging anatomical areas.
• PRP promotes an optimal healing environment, reducing complications and potentially decreasing the need for regrafting.