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Predictive value of the systemic inflammation grade for overall survival in patients with colorectal cancer after surgery: outperforming NLR and mGPS

  • 0Department of General Surgery, Beidahuang Industry Group General Hospital, Harbin, Heilongjiang, China.
Frontiers in Oncology +

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July 2, 2025

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July 2, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

The Systemic Inflammation Grade (SIG) accurately predicts colorectal cancer survival after surgery. This inflammation marker improves risk assessment beyond TNM staging, aiding personalized treatment decisions.

Area Of Science

  • Oncology
  • Cancer Research
  • Clinical Biomarkers

Background

  • Accurate prognostic stratification in colorectal cancer (CRC) post-curative resection is challenging.
  • The Systemic Inflammation Grade (SIG), combining neutrophil-to-lymphocyte ratio (NLR) and modified Glasgow Prognostic Score (mGPS), was developed to enhance risk assessment.

Purpose Of The Study

  • To evaluate the prognostic value of the Systemic Inflammation Grade (SIG) in patients with colorectal cancer (CRC) after curative resection.
  • To compare the accuracy of SIG with existing prognostic markers like NLR, mGPS, and TNM staging.
  • To assess the consistency of SIG's prognostic efficacy across different tumor locations (colon vs. rectum).

Main Methods

  • Retrospective analysis of 263 CRC patients who underwent R0 resection.
  • Calculation of preoperative NLR and mGPS to determine SIG scores (low, medium, high).
  • Evaluation of associations between SIG, clinicopathological variables, chemotherapy compliance, and overall survival (OS) using ROC analysis, Kaplan-Meier curves, and Cox regression.

Main Results

  • Higher SIG scores correlated with elevated CEA, advanced TNM stage, and reduced chemotherapy compliance.
  • Multivariate analysis identified SIG as an independent prognostic factor for OS.
  • SIG demonstrated superior prognostic accuracy (AUC=0.785) compared to NLR, mGPS, and TNM staging.
  • Significant survival differences were observed across SIG groups, with consistent prognostic efficacy in both colon and rectal cancers.

Conclusions

  • The Systemic Inflammation Grade (SIG) is a robust composite biomarker for postoperative risk stratification in colorectal cancer.
  • SIG effectively captures systemic inflammation-driven risk heterogeneity, outperforming existing markers and complementing TNM staging.
  • Its consistent prognostic utility across colon and rectal cancers supports its use in guiding personalized adjuvant therapy and surveillance strategies.

Keywords:

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