Effect of autologous platelet concentrates on osteoblast cell activity during early osseointegration

Advances in implant dentistry focuses on enhancing the predictability of implant success using advanced regenerative techniques. Autologous platelet concentrates rich in growth factors play a crucial role in stimulating osteoblast activity and improving osseointegration at implant sites. Therefore, it is of interest to evaluate the osteogenic efficacy of four injectable platelet concentrates: (1) injectable-platelet-rich fibrin, (2) leukocyte platelet-rich fibrin, (3) advanced platelet-rich fibrin and (4) Advanced platelet-rich fibrin + on titanium surfaces. All tested concentrates enhanced osteoblastic adhesion, differentiation and mineralization, with injectable-platelet-rich fibrin demonstrating the most significant calcium nodule formation. Thus, injectable-platelet-rich fibrin proved to be the most effective in promoting early osseointegration compared to the other platelet-rich fibrin types.