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Risk of cardiovascular events among celiac disease patients: A meta-analysis review

Saad Shams1, Vanessa Vidaurre Corrales2, Ibrahim Marouf Yasin Al Shyyab3

  • 1Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, USA.

Bioinformation
|July 2, 2025
PubMed

Insights

Celiac disease (CD) is linked to a 9.3% prevalence of cardiovascular events. While overall cardiovascular risk and myocardial infarction are not significantly increased, CD patients face higher risks for conditions like atrial fibrillation and heart failure.

Area of Science:

  • Cardiology
  • Gastroenterology
  • Epidemiology

Background:

  • Celiac disease (CD) is an autoimmune disorder triggered by gluten ingestion.
  • Cardiovascular complications are increasingly recognized in patients with CD.
  • Understanding the specific cardiovascular risks associated with CD is crucial for patient management.

Purpose of the Study:

  • To systematically review and meta-analyze the association between celiac disease and various cardiovascular events.
  • To quantify the prevalence of cardiovascular events in the celiac population.
  • To compare cardiovascular risk in celiac patients versus the general population.

Main Methods:

  • Comprehensive literature search across multiple databases.
  • Inclusion of studies reporting cardiovascular events in celiac disease patients.
  • Application of random effects models for meta-analysis.

Main Results:

  • Overall prevalence of cardiovascular events in celiac patients was 9.3%.
  • No significant increase in overall cardiovascular risk or myocardial infarction was observed compared to controls.
  • Celiac disease was associated with a higher risk of atrial fibrillation, stroke, congestive heart failure, and cardiomyopathy.

Conclusions:

  • While not increasing overall cardiovascular risk or myocardial infarction, celiac disease is linked to specific cardiovascular conditions.
  • Close monitoring of cardiovascular health is recommended for individuals with celiac disease.
  • Further research may elucidate the mechanisms underlying these associations and inform preventative strategies.

Keywords:
Celiac diseaseatrial fibrillationcardiovascular eventsmyocardial infarctionstroke

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