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From tumor immunity to precision medicine: the next step in B7-H3/CD276 research

Haolie Fang1, Yuqian Liu1, Gege Wang1

  • 1Zhejiang University School of Medicine, Zhejiang University-University of Edinburgh Institute, Haining, China.

Medical Review (2021)
|July 2, 2025
PubMed

Keywords:
B7-H3/CD276cancer therapeuticscheckpoint inhibitorsimmune evasiontumor microenvironment

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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