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Updated: Sep 17, 2025
High Resolution 3D Imaging of Ex-Vivo Biological Samples by Micro CT
Published on: June 21, 2011
Investigation of the Biological Properties of Non-small Cell Lung Cancer Using Three-dimensional Computed Tomography
Akira Haro1, Sho Wakasu1, Yuka Kozuma1
1Department of Thoracic Surgery, Kitakyushu Municipal Medical Center, Kitakyushu, Japan.
Background/Aim:
We investigated the biological properties of non-small cell lung cancer (NSCLC) using three-dimensional computed tomography (3D-CT) images.
Patients And Methods:
We measured the diameters of surgically resected NSCLCs in the direction to the hilum and in the direction orthogonal to the hilum on the two largest cross-sections using 3D images, and classified NSCLCs into three types according to their shape. Correlations between each type and clinicopathological factors were determined.
Results:
We examined 369 cases: 129 Type A, 182 Type B, and 58 Type C. The tumor-shape types demonstrated significant correlations with histological type, tumor size, and pathological tumor size (pT), lymphatic invasion (Ly), and pleural invasion (pl) factors. There were significant correlations between Type A and adenocarcinoma (Ad), and between Type C and advanced T factor or larger size. The frequency of lymphatic invasion was increased in Type A but decreased in Type C, whereas pleural invasion was increased in Type C.
Conclusion:
NSCLC tumor shapes showed biological properties according to each histological type, such as pleural invasion or lymphatic invasion.
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