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Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
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Key Lipid Reprogramming Revealed in Gastric Signet Ring Cell Carcinoma by Spatial Mass Spectrometry Metabolomics.

Yuying Shi1,2,3, Qi Yang4, Botao Xu5

  • 1National Science Library (Chengdu), Chinese Academy of Sciences, Chengdu 610299, China.

Journal of the American Society for Mass Spectrometry
|July 2, 2025
PubMed
Summary

This study reveals distinct metabolic signatures in gastric signet ring cell carcinoma (GSRC), identifying novel lipid biomarkers. Understanding this metabolic heterogeneity is crucial for developing targeted therapies for this aggressive gastric cancer subtype.

Keywords:
Gastric signet ring cell carcinomamass spectrometry imagingmetabolic heterogeneity

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Area of Science:

  • Metabolomics
  • Cancer Biology
  • Biochemistry

Background:

  • Gastric signet ring cell carcinoma (GSRC) is an aggressive gastric cancer (GC) subtype with poor prognosis.
  • Limited understanding of GSRC's molecular and metabolic heterogeneity hinders clinical progress.

Purpose of the Study:

  • To investigate the metabolic landscape of GSRC using mass spectrometry imaging (MSI).
  • To identify spatial metabolic signatures and lipidomic biomarkers in GSRC tissues of varying differentiation grades.

Main Methods:

  • Mass spectrometry imaging (MSI) for spatial profiling of metabolites and lipids.
  • Multi-omics network analysis to explore metabolic pathways in GSRC progression.

Main Results:

  • Distinct metabolic signatures were identified across different tissue subregions of GSRC.
  • Key lipidomic biomarkers associated with GSRC include phosphatidylethanolamine N-methyl (PE-NMe), phosphatidylethanolamine (PE), sphingomyelin (SM), diacylglycerol (DG), phosphatidic acid (PA), and phosphatidylcholine (PC).
  • Intricate metabolic pathways involved in GSRC progression were revealed through multi-omics network analysis.

Conclusions:

  • The study highlights the significant metabolic heterogeneity within GSRC.
  • Identified lipid biomarkers offer insights into GSRC pathogenesis and potential therapeutic targets.
  • Findings pave the way for future research into the clinical implications and therapeutic strategies for GSRC.