Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

446
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
446
Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

857
Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
857
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

381
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
381
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

225
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
225
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

659
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
659
Opioid Receptors: Overview01:22

Opioid Receptors: Overview

2.0K
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

School closures and parental mental health.

Journal of health economics·2026
Same author

Cross-system collaboration between the child welfare system and substance use treatment providers: a qualitative analysis of strategies, facilitators, and barriers.

BMC health services research·2026
Same author

Insurance coverage and provision of opioid disorder treatment: Evidence from Medicare.

Journal of policy analysis and management : [the journal of the Association for Public Policy Analysis and Management]·2026
Same author

Violence and threat exposure is associated with frontostriatal alterations during risky decision-making in children with co-morbid ADHD and disruptive behavior disorders.

Frontiers in psychiatry·2026
Same author

Understanding the association between medical mistrust, opioid knowledge, and stigma towards adults with a history of an opioid use disorder.

Journal of substance use·2026
Same author

Effectiveness Outcomes from a Social Network Diffusion Intervention to Increase COVID-19 Testing and Vaccination among Individuals Impacted by the Criminal Legal System in Urban U.S. Cities.

Journal of urban health : bulletin of the New York Academy of Medicine·2026

Related Experiment Video

Updated: Sep 17, 2025

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
07:51

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

221

Stalled Improvements? Youth Opioid Misuse 2015-2022.

Nicole Siegal1, Kosali Simon1, Seth Freedman1

  • 1O'Neill School of Public and Environmental Affairs, Indiana University, Bloomington, Indiana.

The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine
|July 2, 2025
PubMed
Summary

Youth opioid misuse rates have flattened and converged across age groups since the COVID-19 pandemic. This trend suggests limited potential for further reductions in adolescent and young adult opioid misuse.

Keywords:
COVID-19FentanylNSDUHOpioid epidemicYouth opioid misuseYouth substance use

More Related Videos

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
09:29

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

2.3K
Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs
10:13

Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs

Published on: November 8, 2024

2.4K

Related Experiment Videos

Last Updated: Sep 17, 2025

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
07:51

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

221
Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
09:29

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

2.3K
Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs
10:13

Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs

Published on: November 8, 2024

2.4K

Area of Science:

  • Public Health
  • Epidemiology
  • Substance Use Research

Background:

  • Opioid misuse among adolescents and young adults is a significant public health concern.
  • Understanding trends in youth opioid misuse is crucial for developing targeted prevention and intervention strategies.

Purpose of the Study:

  • To analyze trends in youth opioid misuse.
  • To compare these trends before, during, and after the COVID-19 pandemic.
  • To examine age-specific patterns in opioid misuse among individuals aged 12-25 years.

Main Methods:

  • Utilized nationally representative data from the National Survey on Drug Use and Health (NSDUH) spanning 2015-2022.
  • Analyzed self-reported opioid misuse data.
  • Stratified analysis by age groups within the 12-25 year range.

Main Results:

  • A pre-pandemic downward trend in youth opioid misuse has plateaued since the onset of the COVID-19 pandemic.
  • The disparities in opioid misuse rates between different age groups within the 12-25 range have diminished.
  • Opioid misuse prevalence was below 5% across all studied age groups by 2020.

Conclusions:

  • The convergence and flattening of youth opioid misuse rates indicate a potential ceiling effect, with limited room for further decline.
  • Despite decreasing misuse rates, rising mortality rates associated with opioid use present a complex public health challenge.
  • The findings underscore the need for continued monitoring and adaptive strategies in addressing youth opioid misuse.