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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Related Experiment Video

Updated: Sep 17, 2025

Clinical Application of Intense Pulsed Light Therapy and Radio Frequency for Treatment of Ocular Surface Diseases
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Dry Eye Disease Management Via Technological Methods: A Systematic Review and Network Meta-analysis.

Dror Ben Ephraim Noyman1, Clara C Chan2, Joshua C Teichman2

  • 1Ophthalmology Department, Rambam Health Care Campus, Ruth Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Ophthalmology and Therapy
|July 2, 2025
PubMed
Summary
This summary is machine-generated.

Advanced treatments like TearCare with meibomian gland expression and intense pulsed light (IPL) show promise for dry eye disease (DED). These therapies offer effective short-term relief for DED symptoms and meibomian gland dysfunction.

Keywords:
Dry eye diseaseIntense pulsed lightMeibomian gland dysfunction

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Area of Science:

  • Ophthalmology
  • Medical Technology
  • Clinical Research

Background:

  • Dry eye disease (DED) pathophysiology is increasingly targeted by novel technological therapeutic modalities.
  • Existing research highlights a growing interest in advanced treatments for DED management.

Purpose of the Study:

  • To systematically evaluate and compare the efficacy of various technological interventions for dry eye disease (DED).
  • To identify the most effective technological treatments for improving key DED outcome measures.

Main Methods:

  • A systematic literature search was performed across PubMed, Scopus, and Embase databases up to July 29, 2023.
  • Randomized controlled trials (RCTs) examining intense pulsed light (IPL), LipiFlow, TearCare, iLux, low-level light therapy (LLLT), and acupuncture for DED were included.
  • A network meta-analysis was conducted to compare treatment efficacy based on standardized mean differences (SMDs) and P-scores.

Main Results:

  • Forty-five RCTs involving 3455 patients were analyzed.
  • TearCare combined with meibomian gland expression (MGX) showed the highest efficacy in improving meibomian gland secretion.
  • Intense pulsed light (IPL)-based treatments, particularly IPL alone, demonstrated significant improvements in tear break-up time (TBUT) and symptom scores, ranking highest for symptom relief.
  • Acupuncture was superior to conservative treatments for increasing tear secretion (Schirmer test values).
  • LipiFlow showed modest improvements but was not significantly superior to other evaluated technologies.

Conclusions:

  • Advanced technological interventions show significant potential for the short-term management of dry eye disease (DED).
  • The study highlights the need for standardized, long-term comparative research to further validate these findings and establish optimal treatment protocols.