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Related Experiment Video

Updated: Sep 17, 2025

Quantification of Hypopigmentation Activity In Vitro
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Melanin Regulation and Autophagy Modulation by Rosa centifolia L. Extract and Its Key Compounds (Astragalin and

Huaqian Mei1, Qilin Li2, Haodong Li2

  • 1Shandong Huawutang Biotechnology Co., Ltd, Jinan, China.

Chemistry & Biodiversity
|July 2, 2025
PubMed
Summary

Rosa centifolia extract effectively whitens skin by inhibiting melanin production and tyrosinase activity. Key compounds like ellagic acid and astragalin demonstrate significant skin-whitening potential through various molecular pathways.

Keywords:
Rosa centifoliaautophagybiological activitymelanogenesisprotein expression

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Area of Science:

  • Cosmetic Science
  • Dermatology
  • Natural Product Chemistry

Background:

  • Rosa centifolia is known for antioxidant and anti-inflammatory effects.
  • Limited research exists on its skin-whitening capabilities.

Purpose of the Study:

  • Investigate Rosa centifolia's skin-whitening properties in vitro.
  • Identify active compounds and their mechanisms of action.

Main Methods:

  • Flash extraction of Rosa centifolia (RCFE) and quantification of flavonoids and proanthocyanidins.
  • HPLC/DAD method established for analyzing ellagic acid (ECA), astragalin (ASG), and isoquercitrin.
  • B16 cell model used to assess the anti-melanogenic effects of RCFE, ECA, and ASG via ELISA and Western Blot.

Main Results:

  • Ellagic acid (3.00 µg/mL) and astragalin (6.00 µg/mL) significantly inhibited melanogenesis and tyrosinase activity.
  • RCFE, ASG, and ECA suppressed melanogenesis, tyrosinase activity, and MITF expression.
  • These compounds affected TRP1 and TRP2 expression and enhanced cellular autophagy, indicated by increased LC3-II/LC3-I ratio and Beclin-1, with decreased p62.

Conclusions:

  • Rosa centifolia extract and its active compounds (ECA, ASG) possess significant skin-whitening potential.
  • The mechanism involves inhibiting melanogenesis, tyrosinase activity, and MITF, while promoting autophagy.
  • Provides a basis for developing R. centifolia-derived ingredients for skincare and pharmaceuticals.